Objective:To study the effectiveness and safety of using hypertonic saline with different concentrations for clinical treatment of cerebral trauma.Method:126 patients with cerebral trauma were selected and divided into two groups randomly. There were 58 cases in the observation group and HS was 7.5%,and there were 68 patients in the control group and HS was 10%. After general ana-esthesia,the patients received the treatment of decompressive craniectomy,and were given puncture of internal jugular vein and indwelling surgery of central venous catheters in which the extraction of venous blood was in deep vein. Lastly,the plasma electrolytes,blood sugar and urea nitrogen of patients were detected every one hour.Result:Before the treatment on cerebral trauma,osmotic pressure of plasma for the patients was in the normal range.The plasma osmotic pressure 6 hours after treatment in the observation group was still in the normal range,but that in the control group was greater,which had evident difference. Conclusion:Applying 7.5%of hypertonic saline is better than applying 10% of HS,and 7.5% of hypertonic saline is more rapid for reducing intracranial hypertension in the process of application compared with 10% of HS. And cerebral perfusion pressure of patients improves. The HS with 7.5% has little effect on crystal osmotic pressure and concentration of plasma electrolytes.% 目的：研究采用不同浓度的高渗盐水对脑外伤临床治疗的有效性和安全性。方法：将126脑外伤患者随机分为观察组58例和对照组68例，观察组注入7.5%的高渗盐水，对照组注入10%的高渗盐水。患者的治疗都需要开展全身的麻醉后，才开始进行骨瓣减压的治疗工作，随后开展颈内静脉的穿刺和深静脉导管的留置手术，静脉血的抽取是从深静脉中进行，最后对患者的血浆电解质和血糖、尿素氮做检测，隔一个小时进行一次。结果：患者开展脑外伤的治疗前，血浆的渗透压都处在正常的范围中，在开展治疗的6 h 后，观察组的血浆渗透压还是处在正常的范围中，而对照组的血浆渗透压的数值偏大，与观察组比较差异有统计学意义。结论：采用7.5%的高渗盐水比10%的高渗盐水更为合适，而且在应用的过程中颅内高压的减降工作也比10%的高渗盐水迅速，患者的脑灌注压上也能有所提升，这个浓度的高渗盐水对晶体渗透压和血浆电解质浓度的影响非常小。
展开▼
