瑞舒伐他汀对不稳定型心绞痛患者支架术后炎性因子的影响

摘要

目的：探讨瑞舒伐他汀对不稳定型心绞痛患者（UA）冠脉支架植入（PCI）术后血清妊娠相关蛋白-A（PAPP-A）和肿瘤坏死因子α（TNF-α）的影响。方法：选取2011年8月-2013年10月本院心内科住院的110例UA患者，按照随机数字表法将其分为瑞舒伐他汀20 mg治疗组（高剂量组）和10 mg治疗组（低剂量组）各55例，另选取正常对照组100例。测定各组入院时及术后1周/1个月PAPP-A及TNF-α水平。结果：PCI术前UA两组血清PAPP-A和TNF-α水平均明显高于对照组，差异均有统计学意义（P<0.01）；术前高剂量组和低剂量组的PAPP-A及TNF-α水平比较差异无统计学意义（P>0.05）。PCI术后1周UA两组的PAPP-A及TNF-α水平均明显低于术前（P<0.01），但仍高于正常对照组（P<0.01）；PCI术后1个月UA两组的血清PAPP-A及TNF-α水平与正常对照组相比较差异均无统计学意义（P>0.05），但高剂量组与低剂量组相比较差异均有统计学意义（P<0.05）。结论：瑞舒伐他汀可以降低UA患者PCI术后PAPP-A及TNF-α的浓度，减轻炎症反应，稳定冠脉粥样硬化斑块。%Objective:To investigate the effects of rosuvastatain in therapy on serum PPAP-A,TNF-αlevels after percutaneous coronary intervention(PCI) in patients with unstable angina(UA).Method:110 patients with UA in our cardiology department from August 2011 to October 2013 were selected,they were randomly divided into the high-dose group and the low-dose group,55 cases in each group.The high-dose group was treated with rosuvastatain 20 mg every day before and after PCI.The low-dose group was treated with rosuvastatain 10 mg every day.100 cases were selected as normal control group.The levels of PAPP-A and TNF-α were detected before PCI and at 1 week,1 month after PCI.Result:The levels of PAPP-A and TNF-α in two UA groups were significantly higher than those in the control group before PCI,the differences were statistically significant(P<0.01).Compared with low-dose group,the levels of PAPP-A and TNF-α in high-dose group were no significance before PCI(P>0.05).The levels of PAPP-A and TNF-α decreased at 1week and 1month after PCI in UA two groups (P<0.01).One week after PCI,the levels of PAPP-A and TNF-α in rosuvastatain in high-dose group and low-dose group were significantly higher than those in the control group(P<0.01).One month after PCI,the levels of inflammatory factors were no difference between UA two groups and control group(P>0.05).While compared with low-dose group,the values in high-dose group were lower(P<0.05). Conclusion:Rosuvastatain can decrease the levels of PAPP-A and TNF-α significantly in patients with UA after PCI, and it is good for the stability of atherosclerotic plaques.