心血瘀阻型胸痹患者同步12导联心电图信号的Lyapunov指数谱分析

摘要

Objective:To investigate the Lyapunov index spectrum analysis of 12-lead ECG signals in Xinxueyuzu chest bi-syndrome. Method:150 patients with coronary heart disease diagnosed by western medicine and Xinxueyuzu chest bi-syndrome diagnosed by traditional Chinese medicine were selected as observation group in our hospital during 2012 October to 2014 October,in the same period,80 healthy persons were selected as control group,the difference of Lyapunov index of synchronous 12 lead ECG signal spectrum were compared between the two groups. Result:The age,smoking,body mass index (IBM),blood pressure,triglyceride(TG),low density lipoprotein cholesterol(LDL-C)level between the two groups had no significant difference(P>0.05),it was comparable. The maximum Lyapunov exponent of ECG signals of synchronous 12 lead(Ⅰ,Ⅱ,Ⅲ,aVR,aVL,aVF,V1,V2,V3,V4,V5 and V6)of the observation group was(0.0201±0.0037),(0.0193±0.0036), (0.0282±0.0057),(0.0276±0.0057),(0.0297±0.0065),(0.0270±0.0059),(0.0273±0.0066),(0.0290±0.0065), (0.0279±0.0068),(0.0277±0.0062),(0.0274±0.0061)and(0.0285±0.0092),which was significantly lower than (0.0649±0.0092),(0.0621±0.0088),(0.0866±0.0010),(0.0880±0.0094),(0.0797±0.0087),(0.0801±0.0087), (0.0826±0.0095),(0.0806±0.0105),(0.0769±0.0099),(0.0864±0.0089),(0.0811±0.0087)and(0.0764±0.0065)of the control group,there was statistically significant difference between the two groups(P<0.05). According to the time sequence reconstruction of phase space diagram and Lyapunov exponent spectrum variation curves,chaotic characteristics of the control group was obvious,observation group was weakened. Conclusion:The maximum Lyapunov can reflect the pathological of chaotic characteristics of synchronous 12 lead ECG signals changes in patients with blood stasis obstruction.%目的：探讨心血瘀阻型胸痹患者同步12导联心电图信号的Lyapunov指数谱。方法：选取本院2012年10月-2014年10月西医诊断冠心病且中医辨证为心血瘀阻型胸痹患者150例为观察组，同期选取80例健康体检者作为对照组，比较两组同步12导联心电图信号的Lyapunov指数谱差异。结果：两组年龄、吸烟史、体重质量指数（IBM）、血压、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平比较，差异均无统计学意义（P>0.05），具有可比性。观察组同步12导联（Ⅰ、Ⅱ、Ⅲ、aVR、aVL、aVF、V1、V2、V3、V4、V5和V6）心电图信号的最大Lyapunov指数分别为（0.0201±0.0037）、（0.0193±0.0036）、（0.0282±0.0057）、（0.0276±0.0057）、（0.0297±0.0065）、（0.0270±0.0059）、（0.0273±0.0066）、（0.0290±0.0065）、（0.0279±0.0068）、（0.0277±0.0062）、（0.0274±0.0061）和（0.0285±0.0092），均明显低于对照组（0.0649±0.0092）、（0.0621±0.0088）、（0.0866±0.0010）、（0.0880±0.0094）、（0.0797±0.0087）、（0.0801±0.0087）、（0.0826±0.0095）、（0.0806±0.0105）、（0.0769±0.0099）、（0.0864±0.0089）、（0.0811±0.0087）和（0.0764±0.0065），比较差异具有统计学意义（P<0.05）。根据时间序列相空间重构图和lyapunov指数谱变化曲线图发现，心电图信号具有明显的混沌特征。结论：同步12导联心电图信号的最大Lyapunov指数可作为心血瘀阻型胸痹的诊断指标。