Predictive factors for the success of “one-off” ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

摘要

Aim:To investigate the technique’s effectiveness and evaluate the risk factors affecting the success of“one-off”percutaneous ultrasound-guided radiofrequency ablation(RFA)for single hepatocellular carcinoma(HCC).Methods:A total of 462 consecutive patients who received RFA from February 2010 to December 2013 at a single center(Eastern Hepatobiliary Surgery Hospital,Shanghai,China)were enrolled in the study.The patients were followed up for at least 6 months.Herein,this study adopted a new terminology named“one-off”ablation which is defined as achieving complete necrosis and no local residual or recurrent tumor within 6 months after single-session RFA.The incidence of“one-off”RFA was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive factors for the success of“one-off”ablation.Results:The technique’s effectiveness was 90.0%(416/462).After 6 months,281 patients achieved“one-off”ablation,while 181 patients failed.On univariate analysis,tumor size≤3 cm and tumor further from organs were found to be significantly correlated with“one-off”complete ablation(P=0.003,and P=0.010,respectively).On multivariate analysis using a logistic regression,tumor size≤3 cm[odds ratio(OR),0.534;95%confidence interval(CI):0.346-0.825,P=0.005]and tumor further from organs(OR,0.593;95%CI:0.387-0.909,P=0.017)remained predictive.Conclusion:Tumor size and tumor location are the predictive factors for the success of“one-off”ablation in patients with single HCC.