Conventional type 1 dendritic cells in protective antitumor immunity and its potential in hepatocellular carcinoma

摘要

Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells.Dendritic cells(DCs)have the capacity to orchestrate the expansion and function of these effector cells both in lymphoid and non-lymphoid tissues of cancer patients.Distinct subtypes of DCs have various capacities to prime and activate different T cell responses.Here,we review conventional type 1 dendritic cells(cDC1s)and their crucial role in protective anti-tumor immunity.Targeting cDC1s as a cancer vaccine against the development of hepatocellular carcinoma will be discussed.