Epidemiological study of premature ventricular contraction in Guangzhou communities

摘要

Background Premature ventricular contractions(PVCs) are associated with an increased risk of morbidity and mortality. Therefore, this study was aimed to assess the prevalence and risk factors of frequent PVCs in Guangzhou communities. Methods Our population-based study included 12013 adults from the permanent residents aged 35 years old and above in 20 communities of Yuexiu District and Panyu District in Guangzhou. Standard 12-lead ECG was performed in 11,634 residents. PVC count was determined by 24-hour Holter ECG in8172 residents. We performed multivariable regression analysis using stepwise backward selection to identify factors independently associated with frequent PVCs(≥ 1% of the total beats). Results Among those who received12-lead ECG, 4,095 were men, accounting for 35.2% of 11634 participants. 1.6% the residents had PVCs and median age was 59 years. 2852(34.9%) were male in 8172 subjects who received 24-hour Holter ECG and 1239 of the 8172 subjects(15.2%) were diagnosed with PVCs by single-lead dynamic electrocardiogram. 2.9% subjects were accounted PVCs exceeded 1% of the total heartbeats, 0.2% subjects were accounted PVC exceeded 10% of the total heartbeats. The multivariable analysis showed that four factors related with frequent premature ventricular contractions included aging(odds ratio(OR) 1.027; 95% CI 1.015 to 1.039), male gender(1.533; 95% CI1.162 to 2.023), high diastolic pressure(1.027; 95% CI 1.015 to 1.039) and long QTc interval(1.016; 95% CI1.005 to 1.027). Besides, frequent vegetable intake(0.225; 95% CI 0.064 to 0.795), high LDL(0.787; 95% CI0.684 to 0.906) and high TG(0.873; 95% CI 0.771 to 0.989) were the protective factors of frequent PVCs. Conclusion PVCs is prevalent in Guangzhou communities. The factors such as age, gender, blood pressure, QTc,vegetable intake, LDL and TG care associated with PVCs.