肿瘤坏死因子TNF-α基因多态性与精神分裂症易感性关系的Meta分析

摘要

Objective An increasing amount of evidence suggests that the schizophrenia is associated with the polymorphisms of tumor necrosis factor-alpha (TNF-α) gene. However, the results of different studies are often inconsistent. So, to investigate the association of TNF-α polymorphisms (-308,-238,-857 and -1031 ) with schizophrenia risk by Meta analysis. Methods Studies and thesises published from 1989 to 2010 were searched through PubMed by the keywords: schizophrenia, TNF a, tumor necrosis factor a, tumor necrosis factor alpha and TNF alpha,and through CNKI by the keywords 多态性( polymorphism), 肿瘤坏死因子( tumor necrosis factor-alpha) and 精神分 裂症(schizophrenia). The results were expressed as odds ratios (OR) and their 95％ confidence intervals (CI).Results 13 studies were found. The results by Meta analysis suggested no significant association between -308 polymorphism and schizophrenia risk ( G/A allele: pooled OR = 1.06, 95％ CI = 0. 79-1.42, P = 0.71 ). No significant difference in genotype distribution of -308 polymorphism in schizophrenia was found. Subgroup analysis also showed that there was no correlation between the populations of Caucasian and Asian. For the -238,-857 and -1031 polymorphisms,Meta analysis showed no correlation with schizophrenia risk. Conclusions There is no significant correlation between TNF-α polymorphisms (-308, -238, -857 and -1031 ) and schizophrenia risk.%目的 有越来越多的证据表明精神分裂症和肿瘤坏死因子α(TNF-α)基因的多态性存在关联,但是许多研究的结果常常是相互矛盾的,因此,我们通过Meta分析的方法来评价TNF-α位点(-308、-238、-857和-1031)多态性和精神分裂症易感性之间的关系.方法 检索PubMed和中国学术期刊网数据库,使用的关键词包括schizophrenia、TNF a、tumor necrosis factor a、tumor necrosis factor alpha、TNF alpha、多态性、肿瘤坏死因子和精神分裂症.检索时间为1989至2010年公开发表的期刊论文.以比数比(OR)及其 95%可信区间(95%CI)为效应尺度.结果 按照纳入标准,共有13篇文献最终进入系统.Meta分析结果表明,-308多态性和精神分裂症不存在明显关联(G/A等位基因:合并OR=1.06,95% CI为0.79～1.42,P=0.71),-308的基因型分布在病例与对照之间亦无明显差异,亚组分析显示,无论是在高加索人种还是亚洲人种中,-308多态性与精神分裂症之间并无明显相关性.对于-238、-857和-1031几个多态性位点的Meta分析,亦未发现与精神分裂症易感性之间存在相关性.结论 TNF-α位点(-308、-238、-857和-1031)的多态性和精神分裂症不存在明显关联.