幽门螺杆菌生物膜形成与其耐药机制的相关性

摘要

Biofilm formation plays an important role in gastrointestinal tract recurrent refractory infections caused by Helicobacter pylori.This review discusses the formation and structure,formation kinetics and quorum sensing system of Helicobacter pylori biofilm,in order to describe the recent advances in the research direction of its drug resistance mechanism.There includes 4 theories,osmosis and nutrient limitation,fighting against immune system,horizontal gene transfer and the anomaly expression of efflux pump genes.This review also summarizes the research progress of prevention strategies to Helicobacter pylori biofilm.%生物膜的形成是幽门螺杆菌引起消化道反复难治性感染的主要因素。本文主要从生物膜的组成结构、形成动力学以及细菌密度感应系统等3个方面探讨幽门螺杆菌生物膜的耐药机制，系统阐述了该研究方向现有的渗透与营养限制、对抗免疫防御系统、基因水平转移和外排泵基因异常表达等4种学说，并对幽门螺杆菌生物膜防治策略的研究进展做一综述。