心血管疾病中髓过氧化物酶的研究进展

摘要

髓过氧化物酶(MPO)存在于髓系细胞(主要是中性粒细胞和单核细胞)中,是白细胞分泌的一种酶,催化形成多种活性氧化剂.MPO除参与防御反应外,还参与了氧化-炎症反应,在动脉粥样硬化及其并发症的发生、发展中发挥了重要的作用.MPO与一氧化氮的催化反应、脂代谢异常、急性冠状动脉综合征等存在密切的关系.文章对MPO在心血管疾病中的研究进展进行了综述.%Myeloperoxidase (MPO) which exists in myeloid cells (mainly in neutrophils and monocytes),is an enzyme derived of leukocytes that catalyzes the formation of numerous reactive oxidant species.Besides innate in defense function,current knowledge has been proved the contribution of these oxidants to tissue injury during inflammation,and MPO plays an important role in the initiation,propagation and acute complications of atherosclerotic process.Growing researches demonstrate the action of MPO as central participant of the link in nitric oxide,lipid metabolism and acute coronary syndrome.This review focuses on the research progress of MPO in cardiovascular diseases.