不育男性精子形态和解脲支原体感染的相关性研究

摘要

Objective To investigate the relationship between ureaplasma urealyticum (UU ) infection and sperm morphology of male infertility by researching the sperm morphology in the patients with UU infection to pro‐vide a experimental reference for the clinical diagnosis and treatment of male infertility .Methods The semen from 285 cases of male infertility in Zhengzhou area and divided into the positive and negative groups according to whether UU infection .Then the morphology and vitality of sperms were compared between the two groups for analyzing the influence effect of UU on male infertility .Results The abnormalities rate of sperm head and tail in the UU positive group was higher than that in the UU negative group (sperm head abnormalities :[(53 .40 ± 5 .21)% ,(50 .10 ± 4 .35)% ;sperm tail abnormalities :(8 .70 ± 2 .31)% ,(3 .60 ± 4 .36)% ,P < 0 .05] .The abnormalities rates of sperm head ,body and tail in the UU positive group were significantly higher than those in the normal group ,the differences were statistically significant[sperm head abnormalities :(53 .40 ± 5 .21)% vs .(34 .20 ± 3 .78)% ;sperm body abnor‐malities :(9 .30 ± 5 .98)% vs .(4 .50 ± 5 .31)% ;sperm tail abnormalities :(8 .70 ± 2 .31)% vs .(4 .10 ± 3 .57)% ;P<0 .05] ;The percentages of sperm vitality grade A and A + B in the UU positive group were (32 .30 ± 3 .82)% and (12 .50 ± 4 .45)% ,which were lower than (38 .50 ± 5 .29)% and (14 .60 ± 3 .67)% in the UU negative group and all were lower than (55 .00 ± 4 .95)% ,(29 .60 ± 5 .31)% in the control group(P< 0 .05) .Conclusion UU infection can affect the morphology and activity of sperm ,thus results in male infertility .%目的：通过对郑州地区解脲支原体感染患者精子形态的研究，探讨解脲支原体感染与不育男性精子形态之间的相关性，为临床诊断和治疗男性不育症提供参考。方法收集285例郑州市地区男性不育症患者的精液，并以是否感染解脲支原体分为阳性组和阴性组，比较2组精子的形态及活力，分析解脲支原体对男性不育的影响作用。结果解脲支原体阳性组精子头部和尾部畸形率高于阴性组，差异有统计学意义[头部畸形：（53．40±5．21）％，（50．10±4．35）％；尾部畸形：（8．70±2．31）％，（3．60±4．36）％；P＜0．05]；解脲支原体阳性组头部、体部和尾部畸形率都明显高于正常组，差异有统计学意义[头部畸形：（53．40±5．21）％，（34．20±3．78）％；体部畸形：（9．30±5．98）％，（4．50±5．31）％；尾部畸形：（8．70±2．31）％，（4．10±3．57）％；P＜0．05]；解脲支原体阳性组精子活力 A 级＋ B 级和 A 级百分率[（32．30±3．82）％，（12．50±4．45）％]均低于阴性组[（38．50±5．29）％，（14．60±3．67）％]，且明显低于正常组，差异有统计学意义[（55．00±4．95）％，（29．60±5．31）％；P＜0．05]。结论解脲支原体感染能够影响精子形态和活力，从而导致男性不育。