AMH、INHB水平对卵巢良性肿瘤患者卵巢储备功能的预测价值

摘要

目的 研究抗苗勒管激素(AMH)、抑制素B(INHB)在卵巢良性肿瘤患者卵巢储备功能预测中的价值.方法 选取2014年6月至2016年6月在陕西省铜川市人民医院择期接受手术治疗的210例卵巢良性肿瘤患者作为研究对象,使用酶联免疫吸附试验(ELISA)对患者手术前的血清AMH、INHB水平进行检测.分析比较不同年龄组(25~30岁组、>30~35岁组、>35~40岁组和>40~45岁组)和不同病理类型组(卵巢囊肿组、卵巢子宫内膜异位囊肿组)之间血清AM H、IN HB水平差异.结果 210例卵巢良性肿瘤患者中,年龄与AMH、INHB均呈明显负相关.卵巢子宫内膜异位囊肿患者的AMH、INHB水平均明显低于单纯卵巢囊肿患者,差异有统计学意义(P<0.05).卵巢子宫内膜异位囊肿组中,双侧患者的AMH、INHB水平均明显低于单侧患者,差异有统计学意义(P<0.05).Pearson相关性分析显示,卵巢良性肿瘤患者中血清AMH与INHB水平间呈明显正相关.结论 血清AM H、IN HB水平与卵巢良性肿瘤患者的年龄关系密切,同时与病理类型有一定相关性.采用AM H、IN-HB水平预测卵巢良性肿瘤患者的卵巢储备功能时,应结合患者的年龄、病理类型等综合考虑.%Objective To analysis and discuss the value of AMH and INHB in prediction of ovarian reserve function in ovarian benign tumor .Methods 210 cases of patients with ovarian benign tumor were selected ,which were treated in Tongchuan People′s Hospital of Shaanxi Province from June 2014 to June 2016 ,the levels of serum AMH and INHB of which were measured by ELISA before the operation .The levels of serum AMH ,INHB between the different age groups (25-30 years old group ,>30-35 years old group ,>35-40 years old group and >40-45 years old group) and different pathological type groups (ovarian cyst group ,o-varian endometriosis cyst group) were analyzed and compared .Results In 210 patients with benign ovarian tumors ,there was a sig-nificant negative correlation between age and AMH or INHB .The levels of AMH and INHB in patients with ovarian endometriosis cyst were significantly lower than those in simple ovarian cysts ,the difference was statistically significant (P<0 .05) .The levels of AMH and INHB in patients with bilateral ovarian endometriosis cyst were lower than those in unilateral ovarian endometriosis cyst ,the difference was statistically significant (P<0 .05) .Pearson correlation analysis showed that there was a significant positive correlation between serum AMH and INHB in patients with ovarian benign tumor .Conclusion The levels of serum AMH and IN-HB were closely related to the age of patients with ovarian benign tumors ,but also correlated with pathological types ,therefore , when the AMH and INHB were used to predict ovarian reserve function of patients with ovarian benign tumors ,the results should be considered combined with the patient′s age ,pathological type and so on .