雌二醇诱导雄性长爪沙鼠乳腺增生模型的初探

摘要

Objective To establish mammary gland hyperplasia model in male Mongolian gerbil induced by estradiol.Methods The male Mongolian gerbils,mouse and rats were respectively ip estradiol benzoate to establish mammary gland hyperplasia model.Observe and compare the mammary gland of the experimental group with the control group.Results Histological observation showed that the mammary gland was not found in the normal male gerbils,and mammary ductal and glandular lobes were found in the male gerbils induced by estrogen.In addition,compared with mouse and rats,the gerbils showed mammary gland hyperplasia with inflammatory cells infiltration.Conclusions The mammary gland hyperplasia was successful replicated in mouse,rats and gerbils induced by estradiol benzoate,and initially demonstrated that Mongolian gerbil can be used as male mammary gland hyperplasia animal model.%目的 建立雌激素诱导雄性长爪沙鼠乳腺增生模型.方法 使用苯甲酸雌二醇腹腔注射诱导雄性长爪沙鼠、小鼠和大鼠,建立乳腺增生模型.取模型动物乳腺组织进行组织学观察,并与正常雄性和雌性长爪沙鼠、小鼠和大鼠进行比较.结果 通过组织学观察,正常雄性长爪沙鼠未见乳腺相关结构,而在苯甲酸雌二醇诱导后的组织中显示较为明显的乳腺导管和乳腺小叶.此外,相比于小鼠和大鼠,长爪沙鼠在雌激素诱导后除了有较明显的乳腺增生外还伴有炎性细胞浸润.结论 苯甲酸雌二醇可以在雄性小鼠、大鼠和长爪沙鼠较好地诱导乳腺增生,初步证实长爪沙鼠可以作为男性乳腺增生动物模型.