基于核酸适体生物传感器的便携式循环伏安测试系统

摘要

Aiming at the problem of inconvenience to carry and difficulty with power in-field electrochemi-cal measurement,a portable cyclic voltammetry measurement system was designed based on aptamer-based biosensor developed by our laboratory.For overcoming the noise in the circuits effectively,a lock-in ampli-fier,potentiostat and program for phase sensitive detection were designed to extract weak signal.Experiment results showed that the system could implement cyclic voltammetry,which had higher SNR(signal noise ra-tio),the measurement precision of which could reach 1 μA.It had features of power saving,and simple era-tion,which could meet the requirement of in-field cyclic voltammetry measurement.%针对现场电化学测试中电化学工作站携带不便、供电困难等问题，设计了一种基于核酸适体生物传感器的便携式循环伏安测试系统。该系统采用实验室研发制备的核酸适体生物传感器设计了锁定放大电路、恒电位电路及相敏检测程序，可实现微弱信号提取，从而有效克服电路系统噪声。实验结果表明，该系统能实现循环伏安测试，具有较高的信噪比，测试精度达到1μA，省电、操作简单，能够满足现场快速准确地进行循环伏安测试的需要。