Study on the serum levels of soluble intercellular adhesion molecule—1（slCAM—1） in patients with Helicobacter pylori Infection

摘要

Objective:To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1(sICAM-1) and Helicobacter pylori(H.pylori) infection in patients with chronic gastritis and peptic ulcer.Methods:The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H.pylori was determined by histologic examination.RUT,14C=UBT,and serology,Ther sera obtained from 18 healthy volunteers served as controls,Results:The serum lervels of sICAM-1 were significantly higher in patients with H.pylori positive than those of H.pylori negative(889.43±32.52ng/mlvs,747.07±30.45ng/ml,P<0.05),The serum levels of sICAM-1 in patients with mild,moderate and severe infection of H.pylori were 841.68±72.36ng/ml,905.43±37.59ng/ml and 1012.54±49.34ng/ml,respectively(P<0.05),The serum levels of sICAM-1 proved to be significantly correlated with the density of H.pylori colonization in gastric mucosa(rs=0.316,P<0.001),The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls(P<0.05).Conclusions:These results indicated that H.pylori infection up-regulates the expression of sICAM-1.