首页>
中文期刊>
《浙江大学学报(英文版)B辑:生物医学与生物技术》
>Identification of genes differentially expressed in monocyte-deriveddendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
Identification of genes differentially expressed in monocyte-deriveddendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D3 on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological nrocess of 1.25-dihvdroxvvitamin D3 on dondritie cells.
展开▼