Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca^2＋ transport

摘要

The authors investigated the influence of green tea polyphenols(GPSs) on the liver mitochondria permeability transition pore(PTP) opening through mitochondria sweling and change ofmitochcodrin membrane potetial .The data showed that GPSs had obvious protective effect on the Ca^2+ -induced PTP opening in a dose-dependent manner detected by mitochondria swelling.The results were obtained by meating the change of mitochondria membrane potential through Rh 123.Further experiments were conducted to examine the detailed influence of GTPs on Ca^2+ import and export of mitochondria.The results showed that GTPs had remarkably inhibitory effect on the Ca^2+-induced Ca^2+ import in mitochondria.and they could accelerate Ca^2+ -release from from mitochondria.Our data provide an altemate interpretation of the potent protective function of GPSs on cell against apoptosis.