癫痫患者脑脊液中多巴胺的改变及意义

摘要

Objective To investigate the changes and significance of dopamine (DA) in the cerebrospinal fluid of patients with epilepsy.Methods A total of 35 epilepsy patients was set as an EP group and then were sub-divided into an intractable epilepsy group (9 patients) and a non-refractory epilepsy group (26 patients).Their cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA) Scale.Their levels of DA in the cerebrospinal fluid were measured by high performance liquid chromatography (HPLC).The association of DA in the cerebrospinal fluid with MoCA scores was analyzed by Spearman correlation analysis.Results The level of DA in the cerebrospinal fluid in the EAP group were significantly higher than that in the control group (P<0.01).No significant difference was found in DA level between the intractable and non-refractory epilepsy groups (P>0.05).There was no significant correlation between DA level and MoCA scores in epilepsy patients (P>0.05).Conclusions The elevated level of DA in the cerebrospinal fluid may be related to the development of EP, but the level of DA is not associated with refractory epilepsy and cognitive dysfunction.%目的 探讨癫痫(EP)患者脑脊液中多巴胺(DA)水平的改变及意义.方法 选择EP患者35例为EP组,根据是否为药物难治性癫痫分为难治性癫痫组9例,非难治性癫痫组26例.设立对照组25例.采用蒙特利尔认知评估量表(MoCA)对EP患者进行认知功能评分,采用高效液相色谱法检测脑脊液DA水平,采用Spearman相关分析脑脊液DA水平与认知功能评分的关系.结果 EP组患者脑脊液DA水平高于对照组,差异有统计学意义(P<0.01),难治性癫痫组脑脊液DA水平与非难治性癫痫组的差异无统计学意义(P>0.05).EP患者脑脊液DA水平与MoCA量表评分无显著相关性(P>0.05).结论 脑脊液DA水平升高可能与EP的发生发展有关,但DA水平与难治性癫痫以及是否合并认知功能障碍无关.