Objective To explore the application and curing effects of the primary complete repair in bladder exstrophy epispadias syndrome in infants.Methods A total of 9 male patients with bladder exstrophy epispadias syndrome underwent neonatal or delayed (more than 30 days)primary closure without pelvic osteotomies.By full extraperitoneal mobilization,bladder,bladder neck and urethra were closed as a single unit,with proper postoperative immobilization.A modified Cantwell-Ransly technique was applied to repair epispadias.Results 7 boys were successfully treated with this procedure.There were 2 cases of de-hiscence of anterior abdominal wall and bladder,with controllable urinary diersion on one of the 2.Mild in-fection of incision occurred in 3 boys,but with good healing effects after the drug treatment and anti-in-flammatory treatment.There was no urinary fistula,urethral stricture,hypospadias,ischemic necrosis of the glans penis or sponge on all boys.All patients had normal conical symmetric glans,with normal serum creatinine level and without vesicoureteral reflux through a 1-year follow-up study.Conclusion Complete primary closure of bladder exstrophy should be conducted according to the size of bladder plate,the degree of symphyseal diastasis and the nutritional condition of the neonate,which is important to avoid the post-operative complications and improve the surgical outcome.%目的：探讨一期手术修复在婴幼儿膀胱外翻尿道上裂综合征治疗中的应用及疗效。方法9例膀胱外翻尿道上裂综合征患者，均为男性，年龄3 d～1岁，平均年龄21．3 w。全部采用 Mitchell 法完全一期修复手术，腹膜外充分游离膀胱，将膀胱、膀胱颈及尿道一同关闭，均未行骨盆截骨术，术后采取适当制动，用改良 Cantwell-Ransley 法修复尿道上裂。结果9例膀胱外翻尿道上裂综合征患者中7例均一期修复成功，2例膀胱、腹壁裂开，其中1例已行可控尿流改道术。3例患儿术后出现轻度切口感染，经换药及抗炎治疗后愈合良好，无一例出现龟头或海绵体缺血坏死，无尿瘘、尿道狭窄及尿道下裂等并发症。术后阴茎外观满意，平均随访1a，肾功均正常，无一例出现膀胱输尿管返流。结论一期手术治疗婴幼儿膀胱外翻尿道上裂综合征疗效可靠，并发症少，临床可推广使用。应根据外翻膀胱大小、耻骨分离程度、患儿一般情况等选择行一期手术修复。
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