Objective:To investigate whether endothelial dysfunction occurred in genetically vulnerable normotensive patients.Methods:Endothelial function was assessed by high-resolution vascular ultrasound.The diameter of brachial arteries were measured at rest.during reactive hyperemia and atfer sublingual nitroglycerine(GTN) in 70 young subjects with a mean age of 44.7(12.1 years:Among them,there were 30 patients with essential hypertension (group 1),20 normotensive patients with a family history of hypertension(group2)and 20 normotensive patients without a family history of cardiovascular diseases that served as controls(group3).Results:Flow-mediated dilatation of brachial arteries was significantly reduced in-roup 1and 2 when compared to group3(Group1:6.8(3.9vs group 2:8.0(3.6vs group3:13.2(5.9%,P<0.01).Conclusion:Endothelium-dependent vasodilatation was impaired in the young normotensive patients with a family history of hypertension.
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