THE EXPESSION OF ENDOTHELIN－1 IN VENTRICULAR SPETAL DEFECT WITH PULMONARY HYPERTENSION

摘要

Objective:To research the expression of endothelin-1(ET-1)in vascular of lung,endocardium and myocardial vascular of congenital heart disease(CHD) ventricular septal defect(VSD)with pulmonary hypertension (PH),Methods:The streptavidin-peroxidase(SP) immunoassay was used to measure the expression of ET-1 in pulmonary arteriola,pulmonary veinlet,endocardium and endangium of vasa coronary of 20 cases VSD of CHD with PH,and contrast the expression level of these 20 cases VSD of CHD with PH.Results:The expression of ET-1 PH patients in pulmonary arteriola,endocardium,and endangium of vasa coronary was much higher than that of the ontrol group(P<0.05),but there was no significance variance in expression level of pulmonary veinlet between two groups(P>0.05),Conclusion:If VSD of CHD was accompany with PH,the degree of PH has a positive correlation with the amount of ET1 in pulmonary arteriola,ET-1 may be the cause of dynamic PH,and also the acceleration factor of the PH.Howerver,the amount of ET-1 in endocardium and endangium of vasa coronary,may have significant conncetion with the myocardium hypertrophy in dynamic PH.