A new method is introduced to study the action between biomaterials and organism. By using an LKB- 2277 bioactivity monitor and ampoule method, the fundamental thermogenesis curves of the metabolic process of pk-15 and the toxic effect of three kinds of selenomorpholine compounds on it were studied at 37℃. From the thermogenesis curves, the heat released by pk-15 metabolism was calculated. The results show that the selenium compounds all have toxic action on the metabolism process of pk-15 at the range of experimental concentrations. The sequence of the toxic action of selenium compounds is: Na2SeO3>β- ( N- selenomorpholine) -ethyl phenyike-tone hydrochloride > selenomorpholine.
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