Preparation and Chiral Recognition of New Chiral Stationary Phases Derived from Cellulose Microspheres

摘要

A new way to prepare cellulose-type chiral stationary phases (CSPs) has been established in the present work.Cellulose microspheres with a volume-average diameter of 11.5 m were prepared by an emulsion-solidification method.Three new CSPs were obtained by crosslinking the cellulose microspheres with terephthaloyl chloride (TPC),and then modifying the crosslinked microspheres with 4-methylbenzoyl chloride,3,5-dimethylbenzoyl chloride and 3,5-dichlorobenzoyl chloride,respectively.The microspheres and the CSPs were characterized by FT-IR,element analysis and scanning electronic microscopy (SEM).The chiral recognition ability of the CSPs was evaluated with high-performance liquid chromatography (HPLC).The chromatographic results demonstrate that the CSP prepared from 3,5-dichlorobenzoyl chloride possesses better chiral recognition ability compared with two other CSPs.