HLA-B*6701 as a Subtype Performing Post-Selected Marking Gene for Cervical Cancer

摘要

A method of sequence-based typing(SBT) has been adopted to assort types of exons 2 and 3,which have the most polymorphism,of HLA-B locus of the Tujia nation group in Hubei province.The correlation among the HLA-B alleles,human papillomavirus(HPV) infection and cervical cancer risk has also been investigated.Under the condition of resident location and age,race unified,100 specimens of cancer patients were sampled as a case group,of which 86 were HPV positive and were screened for HLA-B alleles;while 187 specimens were taken from healthy people,of which 92 were HPV negative as a control group.The result shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group,it was concluded that HLA-B*6701 was only found in the cervical cancer group(p<0.034),which shows that HLA-B*6701 can be used as an important candidate biological marking gene for generation of cervical cancer in Wufeng county of Hubei province.