高压氧治疗对外伤性脑梗死血小板参数的影响及疗效分析

摘要

目的 分析外伤性脑梗死后高压氧对患者血小板计数(PLT)、血小板平均体积(MPV)、血小板体积宽度(PDW)的变化及对预后的影响.方法 将54例外伤性脑梗死分为高压氧组(28例)和对照组(26例),对两组病人治疗后外周血小板参数的变化及预后结果进行统计学分析.结果 伤后6个月按照格拉斯哥预后评分(GOS)和改良Barthel指数(MBI)评定两组治疗效果.高压氧治疗能明显提高外周血小板参数.预后结果评定GOS和MBI测评,P值<0.05,差异显著,有统计学意义.结论 外伤性脑梗死发生后外周PLT下降,MPV和PDW升高,可能对预后的结果产生影响.高压氧治疗可加快提高外周PLT参数,降低MPV和PDW参数,改善脑缺血低氧状态,促进神经细胞功能恢复,对原发伤的救治和防治继发性脑损害,改善预后,降低伤残程度,均起到安全、有效的辅助治疗作用.%Objective To discuss the mechanism and clinical manifestation of traumatic cerebral infarction (TCI) ,the therapeutic effect of hyperbaric oxygen on TCI and changes in platelet parameter( PLT), mean platelet volume (MPV) and platelet distribution width ( PDW). Methods Totally 54 patients with traumatic cerebral infarction were randomly divided into hyperbaric oxygen group (28 patients) and control group (26 patients). The therapeutic effects and change in platelet parameters of the two groups were analyzed statistically. Results There was significant difference between two groups according to Glasgow Outcome Scale(GOS )and Modified Barthel index ( MBI ) at sixth month after injury( P ＜ 0.05 ). Conclusion The decrease of peripheral PLT and the increase of MPV, PDW after onset of TCI can influence the prognosis and outcome of patients with TCI. The HBO can increase PLT and decrease the MPV, PDW of patient with TCI and improve cerebral micro-circulation of cerebral infarction area. The HBO is a safe and effective method in improving outcome and reducing disability in patients with traumatic cerebral infarction.