肿瘤热疗用磁性纳米颗粒制备及其聚集态对升温效果的影响

摘要

目的:获得高磁性的铁氧体纳米颗粒,使其升温效果达到最优,从而更有利于肿瘤磁热疗.方法:通过高温裂解法一步合成均匀稳定的Fe3O4纳米颗粒,将原料从FeCl2替换为MnCl2、ZnCl2可以进一步得到Mn-Zn铁氧体纳米颗粒.通过DMSA修饰替换掉原来颗粒表面的油酸,使之可以溶于水相.结果与讨论:Mn-Zn铁氧体纳米颗粒相对于Fe3O4纳米颗粒具有更高的磁性.修饰后的水溶性纳米颗粒在交变磁场中升温,具有良好的升温效果.通过调节pH的方法对纳米颗粒的聚集状态进行调控,可以改变颗粒的升温效果,进而确认纳米颗粒在交变磁场中的升温效果与其聚集状态有一定关系,从而可以通过调节纳米颗粒的聚集状态来提高升温效果.%Objective: To obtain high magnetic ferrite nanoparticles by metal ion doping, and adjust the aggregation state to optimize the heating effect, which is more conducive to tumor hyperthermia. Method: Uniform and stable Fe3O4 nanoparticles was synthesized by one- pot thermal decomposition method. Mn- Zn ferrite nanoparticles were then obtained by replacing raw material from FeCl2 to MnCl2 , ZnCl2 . DMSA was modified on the surface of particles to replace the original oleic acid, so the nanoparticales were soluble in water phase. Results and Discussion: Mn- Zn ferrite nanoparticles had higher magnetization compared to ferrite nanoparticles. The modified nanoparticles had a good heating effect in an alternating magnetic field. We could control the aggregation state of nanoparticles by adjust pH to change the heating effect of nanoparticles, thus confirming the heating effect of nano- particles was related with its aggregation state, therefore temperature could be raised by adjusting the aggregation of nanoparticles.