反复自然流产患者外周血中Th1/Th2型细胞因子的表达及其意义

摘要

Objective: To determine the concentrations of T helper-1 type( Th1 )/T helper-2 type( Th2 ) cytokine in serum of patient with recurrent spontaneous abortion( RSA )and to study their clinical significance.Methods:The IL-2,TNF-α,IFN-γ and IL-10 concentrations in serum of 56 RSA patients were measured by enzyme-linked immunosorbent assay( ELISA ).64 normal pregnant women in the first trimester about to abort were controls.Results: IL-2,TNF-α,IFN-γ concentrations in serum of RSA were significantly higher than those in normal control group( P ＜ 0.05 ), while IL- 10 concentrations in RSA group were lower than those in normal control group ( P ＜ 0.05 ).Conclusion: Th1/Th2 balance was related to RSA, it maybe one of the important routines transferring RSA.%目的:分析反复自然流产(RSA)患者血清中Th1/Th2型细胞因子水平的变化,探讨其在RSA发病中的意义.方法:采用酶联免疫吸附法检测56例RSA患者血清中Th1(IL-2、TNF-α、IFN-γ)/Th2(IL-10)型细胞因子水平,同时以正常健康早孕组64例作为对照.结果:RSA组血清中IL-2、TNF-α、IFN-γ的水平显著高于对照组(均P＜0.05),而IL-10水平显著低于对照组(P＜0.05).结论:RSA患者血清中Th1与Th2间平衡的改变可能是导致RSA的重要原因之一.