Objective To explore the role of H2 S on acute lung injury induced by paraquat in rats . Methods 50 rats were divided into 5 groups according to exposure time of paraquat and 50 rats were chose as control group .En-dogenous H2 S of the lung tissue were detected and pathology score of lung tissue damage were achieved .4 rats were divided into 4 groups including blank control group ,exposure group ,exposure and exogenous H2 S group ,ex-ogenous H2 S group .Endogenous H2 S of the lung tissue were detected and pathology score of lung tissue damage were achieved after 12 hours . Results The content of endogenous H2 S on acute lung injury induced by paraquat in rats has significant difference at different time points (P<0.01) .Pathology score of lung tissue damage in expo-sure and exogenous H2 S group was lower than exposure group and the difference was statistically significant (P<0.01) . Conclusion The content of endogenous H2 S was negative correlation with the degree of lung injury dur-ing paraquat inducing lung injury and exogenous H 2 S inhibited lung injury in paraquat induced rats .%目的：阐明百草枯中毒致大鼠肺损伤时机体内源性 H2S 的变化，探讨硫化氢在急性百草枯中毒致大鼠肺损伤中的作用。方法按时间点将50只大鼠分为5组，同时染毒；选择对应时间点50只大鼠为对照组。分组检测肺组织中内源性 H2S的含量，并及时处死大鼠，行肺组织损伤病理学评分。另外取大鼠40只分为4组，即空白对照组、染毒组、染毒＋外源性 H 2 S组、外源性 H2S组，于12 h后，检测肺组织中内源性 H2S的含量，并及时处死大鼠，行肺组织损伤病理学评分。结果百草枯中毒致大鼠肺损伤在不同时间范围内，机体内源性 H2S的含量差异有显著统计学意义（P＜0.01）；与染毒组比较，染毒组＋外源性 H2S组肺损伤程度评分显著降低，差异具有显著统计学意义（P＜0.01）。结论百草枯致大鼠肺损伤过程中，内源性 H2S的含量与肺损伤程度呈负相关；外源性 H2S通过增加体内肺组织 H2S的含量，抑制百草枯致肺损伤。。
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