成人生长激素缺乏患者的临床指标与2型糖尿病危险因素的相关性

摘要

目的 探究成人生长激素缺乏(AGHD)患者的相关临床指标与2型糖尿病危险因素的相关性. 方法 回顾性分析我院2014-12～2015-10收治的30例AGHD患者的临床资料,作为研究组;选取同期30例健康体检者作为对照组.分别采用葡萄糖氧化酶法、化学发光法、酶学法以及免疫比浊法检测各项临床生化指标. 结果 研究组和对照组在性别比例、年龄分布、BMI、腰臀比、血压以及空腹血糖(FPG)、胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)方面比较差异并不显著(P＞0.05);研究组患者甘油三酯(TG)、餐后2h血葡萄糖(2hPG)、血浆胰岛素水平(FINS)和血浆高敏C反应蛋白(hs-CRP)水平均高于对照组,低密度脂蛋白胆固醇(HDL-C)低于对照组(P＜0.05). 结论 AGHD患者存在糖脂代谢异常的临床表现,这些异常生理指标与2型糖尿病的多种危险因素显著相关,此类患者继发罹患2型糖尿病的风险较高.%Objective To investigate the correlation between the related clinical indicators in adult patients with growth hormone deficiency (AGHD) and the risk factors of type 2 diabetes mellitus (DM).Methods The clinical data of 30 patients with AGHD admitted to our hospital form December 2014 to October 2015 were analyzed.Thirty healthy physical examination subjects were selected as control group.The biochemical parameters were measured by glucose oxidase method,chemiluminescence,enzyme assay and immune turbidimetry,respectively.Results There was no significant difference in sex,age,BMI,waist to hip ratio,blood pressure,fasting plasma glucose (FPG),cholesterol(TC) and low density lipoprotein cholesterol (LDL-C) between AGHD group and control group (P ＞ 0.05).The triglyceride (TG),2 h postprandial blood glucose (2hPG),plasma insulin (FINS) and plasma high-sensitivity C reactive protein (hs-CRP) levels in AGHD group were significantly higher than in control group,while the level of low density lipoprotein cholesterol(HDL-C) was lower than in control group (P ＜ 0.05).Conclusion The clinical manifestations of abnormal glucose and lipid metabolism in patients with AGHD are significantly correlated with the risk factors of type 2 diabetes,and the patients with AGHD have a higher risk of developing type 2 diabetes.