精神分裂症和抑郁症不同病期体液免疫变化的关系研究

摘要

目的 探讨精神分裂症和抑郁症不同病期体液免疫变化的关系.方法 选取符合ICD-10精神分裂症和抑郁症诊断标准的住院患者各35例,分别在疾病急性期和缓解期抽取晨起空腹静脉血检测免疫球蛋白IgG、IgA、IgM和补体C3、CA的吸光度,将两组结果进行对比,以确定两组疾病在体液免疫方面的变化是否相似.结果 精神分裂症的两期变化是血清免疫球蛋白IgM和补体C3的水平变化显著(P＜0.05),但IgM、IgA和C3在缓解期是升高的,IgG和CA水平降低;抑郁症的两期变化是血清免疫球蛋白IgG、IgM和补体C3的水平均有显著变化(P＜0.05),但其中IgM和C3及IgA的水平在缓解期下降,而IgG和CA的水平升高.结论 精神分裂症和抑郁症在急性期和缓解期体液免疫方面的变化上没有相似性.%Objective To investigate the relationship of the changes of humoral immunity markets in serum at different phases in patients with schizophrenia and patients with depression. Methods A total of 35 inpatients with schizophrenia and 35 inpatients with depression who met the diagnostic criteria of ICD-10 were involved in the study. IgG, IgM, IgA, C3 and C4 of all the subjects at acute phase and the remission phase were detected with ELISA. Wilcoxon signed-rank lest was used to compare the difference of humoral immunity between the two mental disorders. Results Serum levels of IgM, IgA, C3 in schizophrenic patients at remission phase were higher than those at acute phase, levels of IgG and C4 at remission phase were lower than those at acute phase. But only the differences of IgM and C3 reached the significant level (P<0.05). Serum levels of IgM, IgA, C3 in depressive patients at remission phase were lower than those at acute phase, levels of IgG and C4 at remission phase were higher than those at acute phase. But only the differences of IgG, IgM and C3 reached the significant level (P <0.05). Conclusion There was no similarity in the change of serum concentration of humoral immunity markers at different illness phases between patients with schizophria and patients with depression.