牙周炎与慢性阻塞性肺疾病关系的初步研究

摘要

Objective:To explore the relationship between Chronic Obstructive Pulmonary Disease (COPD) and periodontitis. Methods: 498 subjects were recruited in this study and were divided into three groups: mild periodontitis group (77, 15.5%), moderate periodontitis group (143, 28.7%), and severe periodontitis group (278, 55.8%). Clinical examination indexes included probing depth (PD), attachment loss (AL), sulcus bleeding index (SBI), plaque index (PLI) and the level of the alveolar resorption. Lung function of each subjects were also examined. Results: The levels of AL, PLI and alveolar resorption in COPD group were higher than non-COPD group. Significant differences of "FEV1% pre"(F=3.59,P=0.028) and "FEV1/FVC"(F=4.84,P=0.008) were found among different degrees of periodontitis. Negative relationship was found between the level of "FEV1% pre" and the periodontal index (AL, PLI, alveolar resorption), and the same relationship was found for "FEV1/FVC". Conclusion: Correlation is found between COPD and the periodontitis index (AL, PLI, alveolar resorption).%目的:初步探讨牙周炎与慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)的关系.方法:选择符合纳入标准的受试者498 名,其中轻度、中度及重度牙周炎组分别为77 人(15.5%),143 人(28.7%),278 人(55.8%).牙周检查包括:牙周探诊深度(probing depth, PD),牙周附着丧失(attachment loss, AL),龈沟出血指数(sulcus bleeding index, SBI),菌斑指数(plaque index, PLI),牙槽骨吸收水平.通过支气管舒张剂吸入试验测定受试者肺功能水平.结果:COPD组的AL、PLI及牙槽骨吸收水平显著高于非COPD组.其中不同程度牙周炎组之间第1 秒用力呼气容积占预计值的百分比(FEV1%预计值)(F=3.59,P=0.028)及第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)(F=4.84,P=0.008)的差异有统计学意义.支气管舒张剂后"FEV1%预计值"及"FEV1/FVC"与牙周检查指标(AL,PLI,牙槽骨吸收水平)之间均有显著负相关关系.结论:COPD与牙周检查指标(AL,PLI,牙槽骨吸收水平)之间存在相关性.