降钙素预防兔颞下颌关节创伤性骨关节病的实验研究

摘要

Objective: To study the effect of salmon calcitonin on post-traumatic osteoarthrosis in rabbit model.Methods: Post-traumatic osteoarthrosis model was created in 12 New Zealand rabbits.In the treatment group(n =6) salmon calcitonin at 3 μg/kg was given daily for 4 weeks.In the control group( n = 6) normal salin was used.Then the animals were sacrificed, the TMJs were examined by histopathological detections including HE and toluidine blue staining.Modified Mankin's score was used to evaluate the histological change.Results: The histological scores of the control group and treatment group were 9.1 ± 2.7 and 4.2 ± 1.3 respectively ( P ＜ 0.05 ).Conclusion: Salmon calcitonin may be effective in the prevention of TMJ post-traumatic osteoarthrosis.%目的:探讨降钙素对颞下颌关节创伤性骨关节病的预防作用.方法:新西兰大白兔12 只制作颞下颌关节创伤性骨关节病模型,随机分为2 组:降钙素治疗组,对照组.切取TMJ,HE、甲苯胺蓝染色后,组织病理学观察,组织学评分采用改良的Mankin's计分方法.结果:对照组呈现骨关节病表现,治疗组见软骨修复现象.治疗组和对照组组织学评分分别为4.2±1.3、9.1±2.7(P<0.05).结论:降钙素能延缓外伤所致TMJ创伤性骨关节病的发生且明显降低软骨退变的程度.