经导管肝动脉化疗栓塞联合伽玛刀治疗原发性肝癌的临床应用

摘要

Objective To evaluate the therapeutic efficacy of transcathctcr artcral chcmocmbolization ( TACK) combined with radiotherapy-body gamma knife in treatment of hcpatoccllular carcinoma ( HCC). Methods 120 patients with HCC were randomly divided into two groups. 60 of the 120 patients (A group)wcrc treated with TACK! For 1-3 times after given radiotherapy-body gamma knife 2 - 3 weeks. 60 of the 120 patients (B group) were simply treated with beyond two times TACK. The short-term therapeutic effect, survival rate and complications of the patients were assessed. Results The survival rate was 90% in 1 year and 76 %in 2 ycaars in group B, 78. 6 %and 40% in group A, respectively. The difference between group A and B was statistical significance (P＜ 0.05). There was no significant difference of complications in two group s. Conclusion TACK combined with radiotherapy-body gamma knife is a safe and effective method for treating hcpatoccllular carcinoma.%目的 探讨经肝动脉化疗栓塞( TACE)结合立体定向体部伽玛刀治疗肝癌的临床疗效.方法将原发中晚期肝癌120例随机分为A、B 2组.A组(综合组):60例,采用TACE +体部伽玛刀治疗,先行TACE术1～3次后,再进行体部伽玛刀放射治疗,单次剂量为3～6 Gy; B组(介入组):60例,采用单纯TACE术,且行TACE术均在2次以上.并观察比较肿瘤治疗后的近期疗效、患者生存期及并发症.结果综合组与介入组1、2年生存率分别为90% 、76% 和78.6 %、40%,2组生存率比较差异有显著性(P<0.05),2组并发症无明显差别.结论 TACE结合体部伽玛刀治疗原发性肝癌是一种安全、有效的方法.