伴发腰骶椎隐性脊柱裂女性不孕症的内分泌研究

摘要

Objective:To determine the impact of spina bifida occulta (SBO) on the endocrinosity of infertile women. Methods; Clinic data of 1681 female patients with infertility were analyzed retrospectively,among whom 1242 cases with SBO (Group SBO) and 439 cases without SBO( Group NSBO). 180 healthy women at the same age grades (serum hormone assays in 60 cases were respectively performed in follicular phase, ovulation period and luteal phase) were included as control group. Serum hormone assays( FSH, LH, E2 ,P, PRL and T) in follicular phase, ovulation period and luteal phase were compared among the three groups, and the above 6 values were contrastive analyzed between patients with primary infertility and those with secondary infertility in group SBO. Results: There was no statistical difference in the serum hormone levels (FSH, LH, E2,P, PRL and T) in each phase between group NSBO and group N (P＞0.05).The serum hormone levels in each phase of group SBO were all statistical different from the rest both groups (P＜0.05, P＜0.01, respectively). There was no significant difference in serum P level in follicular phase and ovulation period between primary and secondary infertility subgroups in group SBO (P＞0.05), There were significant difference in the serum hormone levels( FSH, LH, E2 ,PRL and T) between primary and secondary infertility subgroups in group SBO (P＜0.05,P＜0.01 respectively). Conclusions; SBO plays a key role on endocrine disorder in women with infertility.%目的:探讨腰骶椎隐性脊柱裂对女性不孕症内分泌状态的影响.方法:回顾性分析1681例女性不孕症患者的临床资料,依照是否伴发隐性脊柱裂分为伴发隐性脊柱裂1242例(SBO组)和不伴有隐性脊柱裂439例(NSBO组),同时选择相同年龄阶段进行了基础内分泌功能检测的180例生殖健康的女性作为正常对照组(分别在卵泡期、排卵期、黄体期检测各60例),对3组基础内分泌功能(包括FSH、LH、E2、P、PRL、T)在卵泡期、排卵期和黄体期的情况进行比较,同时对SBO组中原发不孕和继发不孕患者的以上6项指标进行对照分析.结果:正常对照组和NSBO组在卵泡期、排卵期和黄体期的6项基础内分泌功能测定指标比较,差异均无统计学意义(P＞0.05).SBO组在卵泡期、排卵期和黄体期的6项基础内分泌功能检测结果与正常对照组和NSBO组比较,差异均有统计学意义及高度统计学意义(P ＜0.05,P＜0.01).SBO组内原发不孕组中除卵泡期和排卵期的P值与继发不孕组比较,差异无统计学意义(P＞0.05),其余各项指标在卵泡期、排卵期和黄体期的比较,差异均有统计学意义及高度统计学意义(P＜0.05,P＜0.01).结论:腰骶椎隐性脊柱裂可能会引发女性不孕症患者的内分泌状态失常.