Objective To observe the hemodialysis effect of the new type of concentrated anticoagulant hemodialysate of citrate. Methods Ten dogs were given intermittent hemodialysis and were divided into 3 groups according to hemodialysis manners. Group 1 was saline-flush hemodialysed with bicarbonate hemodialysate; Group 2 was hemodialysed with citrate hemodialysis without any anticoagulant; Group 3 was hemodialysed with bicarbonate hemodialysate and heparin .ACT, Ca 2+, BUN, Cr,ALT, AST, TBIL, DBIL, Na +, Cl -, HCO 3 - and venous pressure were monitored in the animals of each group during hemodialysis. Results During the hemodialysis in Group 1,venous pressure increased lastingly, resulting in the failure of hemodialysis for 2 hours. Hemodialysis for 2 hours in Group 2 were all finished successfully. ACT was extended and Ca 2+ decreased obviously in the venous end during hemodialysis.And ALT?AST?Ca 2+?K +?Na +?Cl -?HCO 3 - after the hemodialysis in Group 2 were not changed(P>0.05).Moreover, the clearance rate of the dialyzers with citrate dialysate increased significantly compared with those of saline-flush and heparin anticoagulation.Conclusion The anticoagulant and dialytic effects of the new type citrate hemodialysis are satisfactory and better than that of
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