THE EXPRESSION AND SIGNIFICANCE OF P53 AND P21(WAF1/CIP1) IN THYROID CARCINOMA

摘要

Thethyroidcanceristhemostcommoncarci nomaintheendocrinicneoplasms.Thyroidcarcino ma,dependingonthepathologicaltype,hastwo thoroughlypolarizedcharacteristicsofprogression. Undifferentiatedcarcinomaischaracterizedbyex ceptionallyquickprogressionwithdireprognosis, whileothertypesshowslowgrowthwithanexcel lentprognosis.Ashasbeenreviewed,P53andP21 playamajorroleinthedevelopmentandprogres sionofmanycarcinomas[1,2].Thisstudyistodocu mentthattheexpressionofP53andP21maybere latedtothetumorigenesisandprognosis...