FOS EXPRESSION IN LUMBARSACRAL SPINAL CORD AND MEDULLA OBLONGATA INDUCED BY CHRONIC COLONIC INFLAMMATION IN RATS

摘要

Irritablebowelsyndrome(IBS)isacommon functionalgastrointestinaldisorderinpopulations.RecentstudieshaveshownthatpersistentIBSsymp tomsdevelopedinbetween7%and31%ofsubjects afterinfectiousgastroenteritisandtransientinflam mationenteritis[1].Thisassociationisnowreferred toaspost infectiousIBS(PI IBS).Visceralhyper sensitivityhasbeenimplicatedinthepathophysiolo gyofPI IBS.Itisproposedthatalteredvisceralper ceptionarisesfromhyperexcitabilityofdorsalhorn neuronsinthecentrallimbofthevisceralafferent system[2].Theev...