Effects of rhubarb extracts on hyperexcitability of hippocampal CA1 neurons after fluid percussion injury

摘要

Traumatic brain injury has become a majorcause of death and disability among young adults[1].Chronic seizures and memory disturbance are majorconsequences of traumatic brain injury,which maybe associated with the dysfunction of the hippocam-pus after braininjury[2-3].It has beenshownthat theamplitude of population spikes collected frompres-ynaptic mossy fibers is increased after traumaticbrain injury in experi ment ani mals[1].Previousstudies have suggested that traumatic brain injurymay lead to the delayed...