双氯芬酸二乙胺凝胶预防化疗性静脉炎的临床观察

摘要

目的 观察双氯芬酸二乙胺凝胶预防化疗性静脉炎的效果.方法 选择吉西他滨和顺铂联合化疗方案的224例化疗患者,将患者按单双日入院静脉化疗分两组,观察组114例,对照组110例,两组均在其他预防静脉炎方法 一致的情况下,输入化疗药物,观察组在穿刺点周围用双氯芬酸二乙胺凝胶均匀涂擦并轻轻按摩,对照组则不使用双氯芬酸二乙胺凝胶,观察比较两组静脉炎的发生率.结果 观察组化疗性静脉炎的发生率低于对照组(χ2=44.59,P<0.01),化疗性静脉炎程度轻于对照组(U=20.52,P<0.01),发生化疗性静脉炎的时间迟于对照组(?字2=3.68,P<0.05).结论 用双氯芬酸二乙胺凝胶预防化疗性静脉炎效果明显,能使化疗性静脉炎的发生率下降,发生程度减轻,发生时间延迟.%Objective To observe the effect of diclofenac diethylamine emugel on the prevention of chemotherapeutic phlebitis. Methods A total of 224 patients undergoing chemotherapy were divided into observation group (n=114) and control group (n=110). Diclofenac diethylamine emugel was applied in puncture point for patients in observation group during chemotherapy while it was not used in control group. The incidence of phlebitis was compared in two groups. Results The incidence of phlebitis in observation group was lower than that in control group (x2=44.59,P<0.01) and the phlebitis was less severe(U=20.52, P<0.01) and its occurrence time later (x2=3.68,P<0.05)in observation group as well. Conclusion Diclofenac diethylamine salt gel is effective in the prevention of chemotherapeutic phlebitis.