Objective To explore the level of serum pepsinogen in gastric diseases and to establish serum peprsinogen standard for screening gastric cancer. Methods Serum pepsinogen level was detected with the two - site " sandwich" technique of enzyme - linked immunosorbent assay ( ELISA). All 351 adult patients were monitored by by endoscopic and pathological method. Results Both serum pepsinogenl (PGI) level and PGI /PG II ratio of patients with chronic atrophic gastritis and gastric cancer were significantly lower than that of patients with chronic superficial gastritis (P <0. 01). Serum pepsinogenl and pepsinogen II (PG II ) levels of cases with gastric ulcer ( GU) were significantly higher than those of patients with chronic superficial gastri-tis ( P < 0. 05 ). Conclusion The changes of serum pepsinogen are correlated with gastric mucosal pathologi-cal changes . T he cutoff value of 43. 37 μg · L-1 for PGI and 2. 47 for PGI /PG Ⅱ ratio can be applied in screening the patients with gastric cancer in Ningxia.%目的 研究胃疾病患者血清胃蛋白酶原水平变化规律并确定适合我区胃癌筛查的血清胃蛋白酶原标准.方法 采用酶联免疫吸附实验(ELISA)对351例患者血清胃蛋酶原亚群(PG Ⅰ、PGⅡ)含量测定,并行胃镜及病理学检查.结果 351例慢性胃疾病及胃癌患者血清胃蛋白酶原水平与胃黏膜病变的程度密切相关,与浅表性胃炎相比萎缩性胃炎、胃癌血清PG Ⅰ、PG Ⅰ/PGⅡ水平明显降低(P＜0.01)；与浅表性胃炎相比消化性溃疡的血清PG Ⅰ、PGⅡ水平明显升高(P＜0.05).我区胃癌筛查的最佳临界值为PG Ⅰ≤43.37μg·L-1或PG Ⅰ/PGⅡ≤2.47,并且灵敏度是94.0％,特异度是55.3％.结论 血清胃蛋白酶原水平与胃黏膜病变的程度密切相关,从灵敏度、特异度分析PG Ⅰ≤43.37μg·L-1、PG Ⅰ/PGⅡ≤2.47,是我区胃癌和慢性萎缩性胃炎筛查较为合适的异常界定值.
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