Objective To investigate the relationship between insulin resistance and colorectal cancer (CRC).Methods Fasting and 2-hour postprandial blood glucose,insulin and insulin re-sistance indexes were compared between 126 patients with newly diagnosed CRC (CRC group) and 137 healthy subjects (control group).In addition,a multiple regression analysis was per-formed to assess the factors influencing CRC.Results Compared with control group,fasting ser-um insulin concentration,postprandial serum insulin concentration and resistance index signifi-cantly increased in CRC group (P<0.05).No significant differences in fasting and postprandial plasma glucose levels were found between the two groups (P>0.05).Multifactor regression a-nalysis showed that insulin resistance had a significant effect on CRC.However,the age,gender, drinking and family history of diabetes had no effects on CRC.Conclusion As an independent risk factor,insulin resistance may increase the risk of CRC.%目的：探讨胰岛素抵抗与结直肠癌患病的关系。方法以新诊断的126例结直肠癌（CRC）患者为病例组（CRC组），以同期体检的137例健康人群作为对照组。比较2组人群空腹及餐后2 h血糖、胰岛素及胰岛素抵抗指数水平间的差异，并对CRC患者的患病进行多因素分析。结果 CRC组的空腹胰岛素水平、餐后胰岛素水平和胰岛素抵抗指数均高于对照组（P＜0．05），而 FPG及 PPG 2组间比较差异无统计学意义（P＞0．05）；多因素回归分析显示年龄、性别、糖尿病家族史及饮酒未进入方程，对结直肠癌未见显著影响；胰岛素抵抗对结直肠癌患病具有显著影响。结论胰岛素抵抗可能会增加罹患结直肠癌的风险，是结直肠癌患病的危险因素。
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