Comments on‘MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche’

摘要

For a long period of time,intestinal mesenchymal stromal cells(IMSC)have been considered as a relatively simple and homogeneous group of cells.These cells could effectively regulate intestinal homeostasis and epithelium integrity via producing growth factors and cytokines(Powell et al.,2011).With the help of single-cell transcriptomics studies,it has now been clear that IMSC are quite complex and heterogeneous(Kinchen et al.,2018).