The C-terminal low-complexity domain involved in liquid-liquid phase separation is required for BRD4 function in vivo

摘要

Dear Editor,Recently,liquid-liquid phase separation(LLPS)attracts great interest for its ability to achieve spatial separation and effective organization of macromolecules(Gomes and Shorter,2018).It is believed to be the driving force to form membraneless organelles and thus plays fundamental roles in a large number of biological processes(Shin and Brangwynne,2017).A list of proteins have been identified that could undergo LLPS in vitro and in vivo(Du and Chen,2018).However,the physiological role of LLPS in animals remains largely unknown.