School of Mathematics;
South China University of Science and Technology;
Guangzhou 510640;
China;
Center for Excellence in Animal Evolution and Genetics;
Chinese Academy of Sciences;
Kunming 650223;
China;
School of Life Science and Technology;
ShanghaiTech University;
Shanghai 200031;
China;
Shanghai Research Center for Brain Science and Brain-Inspired Intelligence;
Shanghai 201210;
China;
School of Life Sciences and Technology;
Tongji University;
Shanghai 200092;
China;
National Research Center for Translational Medicine (Shanghai);
Rui Jin Hospital;
Shanghai Jiao Tong University School of Medicine;
Shanghai 200025;
China;
Graduate School of Medical Life Science;
Yokohama City University;
Yokohama 230-0045;
Japan;
Laboratory for Integrated Cellular Systems;
RIKEN Center for Integrative Medical Sciences (IMS);
Yokohama 230-0045;
Japan;
Key Laboratory of Systems Biology;
Center for Excellence in Molecular Cell Science;
Shanghai Institute of Biochemistry and Cell Biology;
Chinese Academy of Sciences;
Shanghai 200031;
China;
Department of Medical Genome Sciences;
Graduate School of Frontier Sciences;
The University of Tokyo;
Chiba 277-8562;
Japan;
Institute of Industrial Science;
The University of Tokyo;
Tokyo 153-8505;
Japan;
Laboratory of Cell Systems;
Osaka University;
Osaka 565-0871;
Japan;
drug; resistance; breast; cancer; tipping; point; dynamic; network; biomarker; (DNB); molecular; network; mRNA-seq;