Enterohemorrhagic E.coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins

摘要

Dear Editor,Enterohemorrhagic Escherichia coli(EHEC)0157:H7,a major diarrheagenic pathogen,can cause bloody diarrhea,hemorrhagic colitis,and>90%of hemolytic uremic syndrome in humans(Mead and Griffin,1998).Many previous studies have demonstrated that 0157:H7 could disrupt host ubiquitin(Ub)system by delivering virulence effectors into host cells with the type III secretion system(T3SS).NleL(also named EspX7)emerged as one of such effectors,whose E3-like activity was first identified in vitro in 2011(Lin et al.,2011).