Objective To investigate the effects of Saw palmetto and Sanmiaosan on BPH among Chinese males in Hong Kong. Methods The study was designed as a double-blinded placebo-controlled trial. Forty subjects aged 50~80 were randomly divided into two groups, and treated with herbal medicine or placebo for 6 months. Eligible subjects were evaluated by means of International Prostate Symptom Score (IPSS), quality of life (QOL), prostate volume, urinary flow rate (Qmax) and post-void residual volume. Results IPSS total score of herbal drug group showed a significant improvement compared with the placebo group; however, the difference did not attain statistical significance (P = 0.120). IPSS irritative score in herbal drug group showed a significant improvement (P = 0.053), and nocturia also remarkably decreased (P=0.083). Urinary flow rate (Qmax) of herbal drug group after treatment was significantly increased (P=0. 061). The overall effective rate of herbal drug group and placebo group was 70% and 36. 8%, respectively, with a significant difference between the two groups (P = 0. 038). Conclusion Herbal drug was beneficial in improving the lower urinary tract symptoms in patients with benign prosta-tic hyperplasia.%目的 观察三妙散加味治疗良性前列腺增生症的临床疗效.方法 随机双盲安慰剂对照试验,40名年龄50～80岁患者,随机分为对照(安慰剂)组和三妙散加味(舒尿宝)组.观察治疗前后患者的国际前列腺症状评分(IPSS)、生活质量指数(QOL)、前列腺体积(PV)、最大尿流率(Qmax)和膀胱残余尿量(PVR)的变化.结果 IPSS总分虽然舒尿宝组改善较安慰剂组明显,但无统计学意义(P=0.120)；IPSS刺激症状在舒尿宝组有明显改善(P=0.053),夜尿也明显减少(P=0.083).最大尿流率Qmax在舒尿宝组治疗后有明显增加(P=0.061).治疗后舒尿宝组的有效率达70％,安慰剂组为36.8％,两组间有显著性差别(P=0.038).结论 舒尿宝有助于改善前列腺增生患者下尿道症状.
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