不同剂量孕酮针治疗先兆流产临床效果探讨

摘要

Objective To explore the effect of different doses of progesterone (P) in the treatment of threatened abortion. Methods A total of 126 cases of early pregnancy threatened abortion in our hospital from January 2012 to December 2014 were selected and divided into the group A,B and C according to the random number table,42 cases in each group. The three groups were intramuscularly injected by 20,40,60 mg/d of P. The serum P and β-HCG levels after treatment were compared among 3 groups. The cases number of full term pregnancy,adverse reactions and the occurrence rates of missed abortion and complete abortion were compared too. Results The serum P andβ-HCG levels were(49.67±9.62) ng/mL and(5 053.40±90.67)mU/mL for the group A,(50.23±8.24)ng/mL and(5 052.30±88.43)mU/mL for the group B,and(48.54±12.64)ng/mL and(5 054.50±87.65) mU/mL for the group C,the differences among 3 groups were not statistically significant(P>0.05);the cases number of full term pregnancy,occurrence rate of adverse reactions and complete abortion had no statistical differences among 3 groups (P>0.05);the occurrence rate of missed abortion in the group C was significantly higher than that in the group A and B ,the difference was statis-tically significant(P<0.05). Conclusion The pregnancy outcome after P miscarriage prevention treatment in the patients with threatened abortion has no obvious relation with P dose ,but large dose of P could increase the occurrence rate of missed abortion.%目的：探讨不同剂量孕酮（P）治疗先兆流产的临床效果。方法选取该院2012年1月至2014年12月收治的早孕先兆流产患者126例作为研究对象，采用随机数字表法分为A、B、C三组，每组42例，分别给予肌内注射P针每天20、40、60 mg，比较三组患者治疗后血清P、血清β-人绒毛膜促性腺激素（β-HCG）水平，三组患者妊娠至足月例数、不良反应、稽留流产及完全流产发生率。结果 A组：P（49.67±9.62）ng/mL、血清β-HCG（5053.40±90.67）mU/mL；B组：P （50.23±8.24）ng/mL、血清β-HCG（5052.30±88.43）mU/mL；C组：P（48.54±12.64）ng/mL、血清β-HCG（5054.50±87.65）mU/mL；三组孕妇治疗后血清P及β-HCG水平比较，差异均无统计学意义（P＞0.05）；三组患者妊娠至足月、不良反应及完全流产发生率比较，差异无统计学意义（P＞0.05）；C组患者的稽留流产发生率均明显高于A、B组，差异均有统计学意义（P＜0.05）。结论先兆流产患者经P安胎治疗后，妊娠结局与P剂量无明显关系，但大剂量P针会使稽留流产发生率增高。