侵袭性大颗粒淋巴细胞白血病MICM诊断及临床特征分析

摘要

目的 提高侵袭性大颗粒淋巴细胞白血病(LGLL)的认识及鉴别诊断.方法 报告3例侵袭性LGLL的临床特征,MICM实验室检查并结合文献进行复习.结果 1例侵袭性T-LGLL及2例侵袭性NK-LGLL,临床以全身症状明显并有肝、脾肿大,预后极差.且有各自的免疫表型特点,大颗粒淋巴细胞形态及CE,ACP,PAS是LGLL诊断的重要线索.结论 LGLL的诊断需结合临床、细胞学检测、免疫分型综合分析并加以鉴别诊断.%Objective To improve and analyse the diagnose level of large granular lymphocyte leukemia (LGLL). Methods To report 3 cases of patients with aggressive LGLL had found and the review of literature. Results 1 case of T-LGLL and 2 cases of NK-LGLL had aggressive process,their clinical characters were obviously general symptom.hepatomegaly, splenomegaly.these disease develop quickly and had bad prognosis. The immunophenotype had unique feature.Lymphocyte morphology feature and CE,ACP and PAS of Lymphocyte in LGLL patient was the important diagnose clue. Conclusion As a group of heterogeneous disease,the summary diagnose of LGLL should be based on clinical manifestation .lymphocyte morphology feature and immunophenotype and differentiated it carefully.