油橄榄叶提取物对铅中毒小鼠脑中单胺氧化酶活性的影响

摘要

目的：探讨油橄榄叶提取物（OLE）对铅中毒小鼠脑中单胺氧化酶（MAO）活性的影响。方法：选健康小鼠,每日灌胃醋酸铅溶液的同时灌胃不同剂量的OLE进行治疗,连续用药30 d,用比色法检测脑中MAO活性的变化。结果：与正常对照组相比,模型对照组和OLE治疗组小鼠脑中MAO活性明显升高。但小鼠灌胃OLE后脑中MAO的活性与模型对照组相比,明显降低。结论：OLE对铅中毒小鼠脑中MAO活性的增强具有抑制作用。%Objective： to study the effect of olive leaf extracts（OLE） on monoamine oxidase（MAO） in mice brain with lead poisoning.Methods： The health mice were chosen and daily administrating with lead acetate and with different dose of OLE for 30 days.MAO activity in brain was determined by colorimetry.Results： Compared with control group,MAO activity significantly increased in model group and OLE treated group.MAO activity in OLE treated group was lower than that in model group.Conclusion： The lead-induced increase of MAO activity was protected by OLE in mice brain.