粤西地区幽门螺杆菌对抗生素耐药分析

摘要

Objective :To investigate the antibiotic resistance of Helicobacter pylori (H .pylori) isolated from patients in Western Guangdong .Methods :H .pylori was isolated from gastric mucosa biopsy specimens obtained from 600 pa-tients with chronic superficial gastritis or peptic ulcer disease in our hospital ,and then were cultured and identified . Additionally ,H .pylori strains were tested for drug resistance by Kirby-Bauer method .Results:The positive rate of iso-lated H .pylori strains was 78 .5% among 600 patients .The resistance rates for metronidazole ,clarithromycin ,levo-floxacin and amoxicillin were 77 .5% ,20 .4% ,8 .9% and 3 .2% respectively .Conclusion:The first-line antibiotic treat-ment for H .pylori infection in Western Guangdong should be amoxicillin and levofloxacin .In addition ,metronidazole was avoided in the treatment of H .pylori infection ,as well as clarithromycin which was used cautiously .%目的：了解粤西地区幽门螺杆菌（H ．pylori）对抗生素的耐药情况。方法：选择我院确诊的慢性浅表性胃炎或消化性溃疡患者600例，取胃窦黏膜组织进行H ．pylori培养鉴定，采用Kirby-Bauer纸片扩散法对分离菌株进行药敏检测。结果：H ．pylori分离培养阳性率为78．5％；H ．pylori对甲硝唑、克拉霉素、左氧氟沙星及阿莫西林的耐药率分别是77．5％、20．4％、8．9％和3．2％。结论：粤西地区H ．pylori根除治疗的抗生素首选阿莫西林和左氧氟沙星，避免使用甲硝唑，慎重使用克拉霉素。