氨氯地平与二甲双胍联合治疗肥胖型高血压的临床疗效观察

摘要

目的：观察氨氯地平与二甲双胍联合治疗肥胖型高血压的临床效果。方法：将2014年5月－2015年3月我院收治的112例肥胖型高血压患者按照随机数字表法分为研究组和对照组各56例，分别使用氨氯地平与二甲双胍联合治疗、单独应用氨氯地平治疗。比较两组患者的临床疗效、治疗前后BMI、WHR及不良反应发生情况。结果：研究组的总有效率高于对照组，差异有统计学意义（P＜0．05）。治疗后两组BMI和WHR均明显低于治疗前，研究组治疗后BMI和WHR均低于对照组，差异有统计学意义（P＜0．05）。两组不良反应发生率的差异无统计学意义（P＞0．05）。结论：氨氯地平与二甲双胍联合使用治疗肥胖型高血压患者效果确切，效果明显优于单独应用氨氯地平治疗，提高了临床治疗的总有效率，降低体质量及腰臀比，可作为一种治疗肥胖型高血压的有效方法在临床推广应用。%Objective:To observe the clinical effect of obesity hypertension patients treated with amlodipine combina‐tion with metformin .Methods :112 cases of obese hypertensive patients were collected from May 2014 to March 2015 in our hospital were randomly divided into two groups ,there were 56 cases in the study group and the control group ,re‐spectively ,treated with amlodipine and metformin therapy ,amlodipine alone ,respectively .The clinical efficacy ,BMI , WHR before and after treatment ,adverse events of two groups were compared .Results:The total efficiency of the study group were higher than the control group ,the difference was statistically significant (P<0 .05) .After treatment ,BMI and WHR were significantly lower than before treatment ,the study group after treatment BMI and WHR were lower than the control group ,the difference was statistically significant (P<0 .05) .There were no significant difference in incidence of adverse reactions between two group (P>0 .05) .Conclusion:Amlodipine in combination therapy with met‐formin in obese patients with hypertension exact type effects ,better than amlodipine alone ,increasing the overall effi‐ciency of clinical therapy ,reducing body mass and waist‐hip ratio ,can be used as a effective method for clinical applica‐tion in the treatment of obesity hypertension .